Vaccine probe study design

Use of vaccines as probes to define disease burden - The ...

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5/17/2014 · Vaccine probe studies have emerged in the past 15 years as a useful way to characterise disease. By contrast, traditional studies of vaccines focus on defining the vaccine effectiveness or efficacy. The underlying basis for the vaccine probe approach is that the difference in disease burden between vaccinated and unvaccinated individuals can be ascribed to the vaccine-specific pathogen.

Use of vaccines as probes to define disease burden - The ...

The case for a typhoid vaccine probe study and overview of ...

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6/19/2015 · The case for a typhoid vaccine probe study and overview of design elements. ... The primary outcome of a vaccine probe study is the vaccine preventable disease incidence (also known as the vaccine attributable rate reduction), which is defined as the difference in incidence between control and intervention populations, or, mathematically ...

The case for a typhoid vaccine probe study and overview of ...

THE CASE FOR A TYPHOID VACCINE PROBE STUDY AND …

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6/19/2015 · A vaccine probe study using vaccine with unknown properties in the target population should have a nested immunogenicity study. In addition to short-term immunogenicity assessment, such a study should follow a subset of vaccinated children over the study duration to …

THE CASE FOR A TYPHOID VACCINE PROBE STUDY AND …

Use of vaccines as probes to define disease burden

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5/17/2014 · By contrast, traditional studies of vaccines focus on defining the vaccine effectiveness or efficacy. The underlying basis for the vaccine probe approach is that the difference in disease burden between vaccinated and unvaccinated individuals can be ascribed to the vaccine-specific pathogen. ... However, the vaccine probe study design showed a ...

Use of vaccines as probes to define disease burden

Use of vaccines as probes to define disease burden ...

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5/23/2014 · Use of vaccines as probes to define disease burden. ... A vaccine probe study is a randomised clinical trial of a vaccine of known efficacy; the difference in the incidence of disease between vaccinated and unvaccinated people represents the vaccine-preventable disease incidence (VPDI). ... However, the vaccine probe study design showed a ...

Use of vaccines as probes to define disease burden ...

The case for a typhoid vaccine probe study and overview of ...

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Recent advances in typhoid vaccine, and consideration of support from Gavi, the Vaccine Alliance, raise the possibility that some endemic countries will introduce typhoid vaccine into public immunization programs. This decision, however, is limited by lack of definitive information on disease burden. We propose use of a vaccine probe study approach.

The case for a typhoid vaccine probe study and overview of ...

Prospective Randomized Open Blinded End-point (PROBE ...

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THE PROBE DESIGN The Prospective Randomized Open Blinded End-point (PROBE) study is a highly cost-effective alternative to the double-blind, prospective study design. This design utilizes a strict randomization procedure to allocate patients to different treatment regimens. The conti- nuous follow-up and treatment of patients is conducted

Prospective Randomized Open Blinded End-point (PROBE ...

The case for a typhoid vaccine probe study and overview of ...

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6/19/2015 · The case for a typhoid vaccine probe study and overview of design elements. ... is limited by lack of definitive information on disease burden. We propose use of a vaccine probe study approach. This approach would more clearly assess the total burden of typhoid across different syndromic groups and account for lack of access to care, poor ...

The case for a typhoid vaccine probe study and overview of ...

Bangladesh Vaccine Trials - who.int

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Study site- Matlab, 819 children 12 to 35 months already enrolled Flu Vaccine study, 1-3 years- Ongoing Flu Vaccine study, 3-8 years- Completed To evaluate the safety, immunogenicity and efficacy of FLU Q- QIV vaccine in the prevention of influenza A and/or B disease Vaccine – H1N1, H3N2 and two B strain Victoria and Yamagata lineage

Bangladesh Vaccine Trials - who.int

Immunogenicity and Safety Study of Inactivated Subunit ...

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The purpose of this study is to evaluate the immunogenicity and safety of inactivated subunit H5N1 influenza vaccine in individuals who have previously received live attenuated H2N2, H6N1, or H9N2 influenza vaccine, as well as in individuals who have never previously received H5N1 or other pandemic live attenuated influenza vaccines.

Immunogenicity and Safety Study of Inactivated Subunit ...

The case for a typhoid vaccine probe study and overview of ...

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Request PDF on ResearchGate | The case for a typhoid vaccine probe study and overview of design elements | Recent advances in typhoid vaccine, and consideration of support from Gavi, the Vaccine ...

The case for a typhoid vaccine probe study and overview of ...

The case for a typhoid vaccine probe study and overview of ...

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The case for a typhoid vaccine probe study and overview of design elements. Vaccine. ... We propose use of a vaccine probe study approach. This approach would more clearly assess the total burden of typhoid across different syndromic groups and account for lack of access to care, poor diagnostics, incomplete laboratory testing, lack of ...

The case for a typhoid vaccine probe study and overview of ...

Use of oral cholera vaccine as a vaccine probe to ...

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In this study, we used oral cholera vaccine as a probe to investigate the reliability of conventional culture as a diagnostic for cholera by measuring the effectiveness of the vaccine against cholera culture-negative acute watery diarrhea. We did not find any evidence of protection, implying that the culture diagnostics used were reliable.

Use of oral cholera vaccine as a vaccine probe to ...

Role of Streptococcus pneumoniae in Hospitalization for ...

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Conclusions: This vaccine-probe design study suggests that in a setting with high HIV and TB prevalence, culture-confirmed PTB in African children, which frequently presents with symptoms of acute pneumonia, is probably associated with superimposed pneumococcal pneumonia. Children admitted with pneumonia in these settings should be investigated ...

Role of Streptococcus pneumoniae in Hospitalization for ...

Multi-center surveillance for pneumonia & meningitis among ...

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Multi-center surveillance for pneumonia & meningitis among children (<2 yr) for Hib vaccine probe trial preparation in India Madhu Gupta 1, Rajesh Kumar , Alok Kumar Deb 2, Sujit Kumar ...

Multi-center surveillance for pneumonia & meningitis among ...

Incidences of vaccine-preventable Haemophilus influenzae ...

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the primary result of interest in a vaccine-probe study is the incidence of vaccine-preventable disease. The vaccine-probe approach assumes that Hib vaccine does not affect the incidence of disease syndromes other than by prevention of disease caused by Hib. ... Thus, our vaccine-probe design appears to have found that non-severe disease ...

Incidences of vaccine-preventable Haemophilus influenzae ...

Interpreting Vaccine Efficacy | Clinical Infectious ...

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5/15/2005 · The vaccine probe technique has been used more recently in an analysis of a large Hib conjugate vaccine ... but much valuable additional information can be gained by including in the study design and in the formal analytical plan a measurement of the impact of the vaccine on a range of conditions in which the causative organism may have a ...

Interpreting Vaccine Efficacy | Clinical Infectious ...

DC Vaccine for Patients With Ductal Carcinoma In Situ ...

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Study Design. Go to ... The vaccine needle will be placed under the probe, and guided by the ultrasound machine to the groin lymph nodes or axillary nodes. The intralesional vaccine will be directly injected into the quadrant of the breast affected with DCIS. The location will be determined by referring to the patient's mammogram.

DC Vaccine for Patients With Ductal Carcinoma In Situ ...

Validation of Production Processes for Vaccines for WHO ...

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Page 2 of 37 This guidance document “Validation of Production Processes for Vaccines for WHO Prequalification - Compliance Expectations” is one of a series developed by WHO/EMP/VQR team upon request from the manufacturers’ members of the Developing Countries Vaccine Manufacturers Network (DCVMN), with funds from USAID.

Validation of Production Processes for Vaccines for WHO ...

A 9-Valent HPV Vaccine against Infection and ...

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Study Design. We conducted a randomized, international, multicenter, double-blind study of the immunogenicity, efficacy, and side-effect profile of the 9vHPV vaccine in women 16 to 26 years of age.

A 9-Valent HPV Vaccine against Infection and ...

Multi-center surveillance for pneumonia & meningitis among ...

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Multi-center surveillance for pneumonia & meningitis among children (2 yr) for Hib vaccine probe trial preparation in India.

Multi-center surveillance for pneumonia & meningitis among ...
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