Sadhart chf study

Safety and Efficacy of Sertraline for Depression in ...

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Trial Design. The SADHART-CHF study is an NIMH sponsored, prospective, randomized, double-blind, placebo-controlled study that is designed to assess the safety and efficacy of sertraline in the treatment of HF patients with MDD.

Safety and Efficacy of Sertraline for Depression in ...

Safety and Efficacy of Sertraline for Depression in ...

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8/24/2010 · These data suggested the safety profile of sertraline was adequate to permit testing in the heart failure population. The objective of the SADHART-CHF (S ertraline A gainst D epression and H e art D isease in CHF) study was to evaluate the safety and efficacy of sertraline in patients with depression and heart failure.

Safety and Efficacy of Sertraline for Depression in ...

Antidepressant Medication Treatment for Depression in ...

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Antidepressant Medication Treatment for Depression in Individuals With Chronic Heart Failure (SADHART-CHF) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.

Antidepressant Medication Treatment for Depression in ...

Depression and Heart Failure? Put Down the SSRI ...

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12. O’Connor CM, Jiang W, Kuchibhatla M, et al, SADHART-CHF Investigators. Safety and efficacy of sertraline for depression in patients with heart failure: results of the SADHART-CHF (Sertraline Against Depression and Heart Disease in Chronic Heart Failure) trial. J Am Coll Cardiol. 2010;56(9):692-699. 13. Health Quality Ontario.

Depression and Heart Failure? Put Down the SSRI ...

Safety and Efficacy of Sertraline for Depression in ...

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8/24/2010 · Study design. The SADHART-CHF trial tested the hypothesis that sertraline would improve symptoms of depression and reduce cardiac events and morbidity/mortality in HF patients with clinical depression to a greater extent than placebo. Eligible participants were randomized 1:1 to sertraline or matching placebo for the 12-week treatment period.

Safety and Efficacy of Sertraline for Depression in ...

SADHART-CHF: Nurse Intervention Impresses for Depression in HF

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"SADHART-CHF raises the really intriguing possibility that nonpharmacologic therapy may be more effective [for depression] than pharmacologic therapy in patients with heart failure," according to ...

SADHART-CHF: Nurse Intervention Impresses for Depression in HF

Safety and Efficacy of Sertraline for Depression in ...

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The SADHART-CHF study is designed to address this issue. This trial plans to recruit 500 patients with chronic HF and a clinical diagnosis of MDD. Through randomization procedures, half the participants are treated with sertraline and the other half are given placebo for a total of 12 weeks acute treatment. ...

Safety and Efficacy of Sertraline for Depression in ...

SSRIs for depression/heart failure patients? Not so fast ...

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SSRIs for depression/heart failure patients? Not so fast . J Fam Pract. 2017 September;66(9):564-567. ... the SADHART-CHF (Sertraline Against Depression and Heart Disease in Chronic Heart Failure) study, looked at treatment with SSRIs in patients with heart failure and depression. 12 In this trial, ... STUDY SUMMARY SADHART-CHF, but better.

SSRIs for depression/heart failure patients? Not so fast ...

Sertraline Against Depression and Heart Disease in Chronic ...

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Description: Depression is a common comorbidity in patients with chronic heart failure (CHF). The SADHART-CHF trial sought to study if treatment with an antidepressant, sertraline (a selective serotonin reuptake inhibitor [SSRI]) would be associated with benefit in patients with CHF and depression.

Sertraline Against Depression and Heart Disease in Chronic ...

Safety and Efficacy of Sertraline for Depression in ...

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8/24/2010 · (2008) Safety and efficacy of sertraline for depression in patients with CHF (SADHART-CHF): a randomized, double-blind, placebo-controlled trial of sertraline for major depression with congestive heart failure. Am Heart J 156: 437 – 444.

Safety and Efficacy of Sertraline for Depression in ...

Health Status and Depression Remission in Patients With ...

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Study Description. A complete description of the SADHART-CHF trial design and primary findings has been published in detail elsewhere. 12 – 14 In brief, SADHART-CHF is the first and the largest randomized clinical trial examining the effects of a selective serotonin reuptake inhibitor on depression and cardiac outcomes in patient with HF and comorbid major depressive disorder.

Health Status and Depression Remission in Patients With ...

Safety and Efficacy of Sertraline for Depression in ...

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The Safety and Efficacy of Sertraline for Depression in Patients with Chronic Heart Failure (SADHART-CHF) study is a National Institute of Mental Health–sponsored, prospective, randomized, double-blind, placebo-controlled study that is designed to assess the safety and efficacy of sertraline in the treatment of patients with HF with MDD.

Safety and Efficacy of Sertraline for Depression in ...

Health Status and Depression Remission in Patients With ...

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patients with HF, this study examined whether antidepressant intervention and successful depression treatment (ie, remission from depression), affect the health status. A secondary analysis is conducted from the Sertraline Against Depression and Heart Disease in Chronic …

Health Status and Depression Remission in Patients With ...

Depression In Patients and Heart Failure - cfrjournal.com

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10/5/2016 · The prevalence of major depression in chronic heart failure (HF) is about 20–40 %, which is 4–5 % higher than in the normal population. 1–3 Depression in heart failure has become a major issue as the burden of heart failure has continued to increase, and many studies have suggested poorer outcomes in HF patients reporting depression. 4–8 The cost of managing HF has continued to ...

Depression In Patients and Heart Failure - cfrjournal.com

Safety and Efficacy of Sertraline for Depression in ...

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Chronic Heart Failure) trial was to evaluate the safety and efficacy of sertraline in patients with depression and HF. Methods The SADHART-CHF trial was a randomized, double-blind trial of sertraline or placebo in 469 participants with HF and clinical depression. The study was conducted at 3 …

Safety and Efficacy of Sertraline for Depression in ...

Controlling depression is associated with improved health ...

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10/30/2012 · The SADHART-CHF study was funded by the National Institute of Mental Health (grant number R01 MH063211-05). In addition to Xiong and Jiang, the study authors were Maragatha Kuchibhatla of the Duke Clinical Research Institute, and Mona Fiuzat, Ranga Krishnan and Christopher O'Connor of Duke University Medical Center.

Controlling depression is associated with improved health ...

Characteristics of Depression Remission and Its Relation ...

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Request PDF on ResearchGate | Characteristics of Depression Remission and Its Relation with Cardiovascular Outcome among Patients with Chronic Heart Failure (From the SADHART-CHF Study ...

Characteristics of Depression Remission and Its Relation ...

Depression in Heart Failure | JACC: Heart Failure

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10/1/2018 · ![Figure][1] This month’s issue of JACC: Heart Failure includes a focus on comorbidities in heart failure. As a clinician and investigator, I have always been fascinated with the mind–heart interaction. Early in my career, I became particularly interested in mood disorders and mental

Depression in Heart Failure | JACC: Heart Failure

Trajectory Classes of Depression in a Randomized ...

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The objective of this article was to determine whether, in drug intervention trials, growth mixture modeling (GMM) is able to identify drug-responsive trajectory classes that are not evident in traditional growth modeling approaches.

Trajectory Classes of Depression in a Randomized ...

(PDF) Safety and Efficacy of Sertraline for Depression in ...

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The SADHART-CHF study confirmed that patients SAE Type Sertraline Placebo (n ⴝ 194) (n ⴝ 98) (n ⴝ 96) p Value with depression and HF remain at high risk of an adverse Cardiovascular 69 (35.6)* 72 (37.1)* 0.79 outcome, with a mortality rate of 7% at 12 weeks. ...

(PDF) Safety and Efficacy of Sertraline for Depression in ...

Safety and Efficacy of Sertraline for Depression in ...

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Safety and Efficacy of Sertraline for Depression in Patients with CHF (SADHART-CHF): A Randomized, Double-Blind, Placebo-Controlled Trial of Sertraline for Major Depression with Congestive Heart ...

Safety and Efficacy of Sertraline for Depression in ...
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